Stable hydrogen supply helps to enhance the efficiency, lifespan and stability of fuel cell systems. For the 100 kW fuel cell system, the development of anode control strategy was conducted. A feedforward PI controller was used to regulate the anode hydrogen inlet pressure. Furthermore, the control strategy of the circulation pump and the exhaust valve were designed. The simulation results indicate that the feedforward PI control offers faster response velocity and higher stability than traditional PI control. The bench test results demonstrate that the anode pressure control accuracy reaches 98.93%, and the power tracking control accuracy achieves 98.78%. The maximum efficiency of fuel cell stack reaches 72.06%, while the maximum efficiency of fuel cell power generation system reahces 57.85%. This anode control strategy effectively achieves the stable control of hydrogen supply system in fuel cells.