For self-developed piezoelectric injectors and piezo actuators, the 6-cylinder piezoelectric injector drive control circuit with ADμC841 microcontroller and IGBT switch tube was designed based on a pulse width modulation (PWM) control mode. The MATLAB/SIMULINK was then used to optimize the key parameters of the drive circuit. Finally, the designed drive circuit was verified by piezoelectric actuator and piezoelectric injector test. The test results show that the driving voltage can reach 180V, the peak current is 25A and the response time of  driving circuit is less than 0.2 ms when the equivalent capacitance of piezoelectric actuator is 6.8μF. Accordingly, the designed drive control circuit can realize precise and fast control of the piezo injector, which meets the multiple injection requirements at least twice.