The spatial distribution characteristics of load and stress of turbine blade for the TiAl turbine of vehicle turbocharger were analyzed and the turbine blade fracture caused by high temperature was determined as one of the potential turbine failure modes. Then the high temperature rupture property of TiAl turbine was studied through test and the mathematical relationship between the high temperature life and the stress and temperature parameters was built. Based on the endurance test profile of vehicle engine, the high temperature life prediction model of TiAl turbine was further developed and the high temperature rupture life of TiAl turbine was predicted with the model. The result shows that the high temperature life of TiAl turbine is longer than the set service life, which can meet the application demands.