In order to verify the accuracy of thermal structural coupling simulation analysis, a certain type of turbine housing of turbocharger was taken as the research object. The synchronous coupling simulation and calculation of turbine end temperature field was conducted by using CFD and FEA software, the gained joint temperature of temperature field was input to structural analysis model and the thermal stress of turbine housing model was solved. With the same boundary parameters as simulation, the turbocharger ran on the engine test bench and the temperature field and strain distributions of inspection area were measured by using the thermal infrared imager and noncontact strain measurement system respectively. The temperature and stain results were acquired and compared with simulation results. The results show that the temperature and strain accuracy of turbine housing can meet engineering design requirements.