The internal flow characteristics of impeller with double splitters were simulated in order to strengthen the performance of compressor based on a high pressure and transonic centrifugal impeller. The results show that the use of double splitter can improve the flow state at chocking point and decrease the shock wave intensity and main blade loading. With the increase of rotational speed, the pressure ratio of compressor increases obviously. Under the constraint of blade number, two kinds of impellers with double splitter have their own characteristics. Accordingly, the results can provide a new idea for the optimization of high pressure ratio centrifugal compressor.